大分大学医学部整形外科学教室Department of Orthopaedic Surgery, Oita University

研究業績集Research achievement archive

2017年

Notani N, Miyazaki M, Yoshiiwa T, Ishihara T, Kanezaki S, Tsumura H.

Dynamic paraspinal muscle impingement causing acute hemiplegia after C1 posterior arch laminectomy: A case report.
Medicine (Baltimore). 2017 Dec;96(50):e9264. doi:10.1097/MD.0000000000009264. PubMed PMID: 29390372; PubMed Central PMCID:PMC5815784.

Miyazaki M, Kanezaki S, Notani N, Ishihara T, Tsumura H.

Spondylectomy and lateral lumbar interbody fusion for thoracolumbar kyphosis in an adult with achondroplasia: A case report.
Medicine (Baltimore). 2017 Dec;96(49):e8983. doi: 10.1097/MD.0000000000008983. PubMed PMID: 29245270; PubMed Central PMCID:PMC5728885.

Abe T, Kaku N, Tabata T, Tagomori H, Tsumura H.

Clinical results of hemiarthroplasty using new bipolar cups for stage 3 or lower osteonecrosis of the femoral head: a retrospective study.
Musculoskelet Surg. 2017 Nov 18. doi:10.1007/s12306-017-0524-6. [Epub ahead of print] PubMed PMID: 29151233.

Notani N, Miyazaki M, Kanezaki S, Ishihara T, Tsumura H.

Surgical outcomes of laminoplasty for cervical spondylotic myelopathy in very elderly patients (older than 80 years): Time from symptom onset to surgery and changes in spinal cord signal intensity on MRI.
Clin Neurol Neurosurg. 2017 Sep;160:78-82. doi:10.1016/j.clineuro.2017.06.019. Epub 2017 Jul 1. PubMed PMID: 28692908.

Kawano M, Tanaka K, Itonaga I, Iwasaki T, Tsumura H.

MicroRNA-20b promotes cell proliferation via targeting of TGF-β receptor II and upregulates MYC expression in Ewing's sarcoma cells.
Int J Oncol. 2017 Dec;51(6):1842-1850. doi: 10.3892/ijo.2017.4155. Epub 2017 Oct 12. PubMed PMID: 29039480.

Miyazaki M, Notani N, Ishihara T, Kanezaki S, Tsumura H.

Surgical outcomes after laminoplasty for cervical spondylotic myelopathy: A focus on the dynamic factors and signal intensity changes in the intramedullary spinal cord on MRI.
Clin Neurol Neurosurg. 2017 Nov;162:108-114. doi: 10.1016/j.clineuro.2017.10.003.Epub 2017 Oct 4. PubMed PMID: 29017106.

Notani N, Miyazaki M, Kanezaki S, Ishihara T, Tsumura H.

Surgical outcomes of laminoplasty for cervical spondylotic myelopathy in very elderly patients (older than 80 years): Time from symptom onset to surgery and changes in spinal cord signal intensity on MRI.
Clin Neurol Neurosurg. 2017 Sep;160:78-82. doi:10.1016/j.clineuro.2017.06.019. Epub 2017 Jul 1. PubMed PMID: 28692908.

Kaku N, Tabata T, Tagomori H, Tsumura H.

Isolated acetabular revision with femoral stem retention after bipolar hip arthroplasty.
Arch Orthop Trauma Surg.2017 Mar;137(3):425-430. doi: 0.1007/s00402-017-2633-y. Epub 2017 Feb 1. PubMed PMID: 28150224.

Notani N, Miyazaki M, Kanezaki S, Ishihara T, Kawano M, Tsumura H.

Comparison of morphology between patients with and without developmental spinal canalstenosis to inform the feasibility of C1 lateral mass screw insertion in theatlas.
J Orthop Sci. 2017 Mar;22(2):207-212. doi: 10.1016/j.jos.2016.11.019. Epub 2016 Dec 23. PubMed PMID: 28017708.

Ishihara T, Miyazaki M, Notani N, Kanezaki S, Kawano M, Tsumura H.

Locally Applied Simvastatin Promotes Bone Formation in a Rat Model of Spinal Fusion.
J Orthop Res. 2017 Sep;35(9):1942-1948. doi: 10.1002/jor.23479. Epub 2016 Dec 14.PubMed PMID: 27862237.

Notani N, Miyazaki M, Kanezaki S, Ishihara T, Kawano M, Tsumura H.

Surgical management of ventrally located spinal meningiomas via posterior approach.
Eur J Orthop Surg Traumatol. 2017 Feb;27(2):181-186. doi: 10.1007/s00590-016-1860-1. Epub 2016 Sep 26. PubMed PMID: 27671472.

Hirakawa M, Miyazaki M, Ikeda S, Matsumoto Y, Kondo M, Tsumura H.

Evaluation of the rotational alignment of the tibial component in total knee arthroplasty: position prioritizing maximum coverage.
Eur J Orthop Surg Traumatol. 2017Jan;27(1):119-124. doi: 10.1007/s00590-016-1850-3. Epub 2016 Sep 10. PubMed PMID:27614951.

Notani N, Miyazaki M, Yoshiiwa T, Ishihara T, Tsumura H.

Acute celiac artery compression syndrome after extensive correction of sagittal balance on an adultspinal deformity.
Eur Spine J. 2017 May;26(Suppl 1):31-35. doi:10.1007/s00586-016-4676-0. Epub 2016 Jun 23. PubMed PMID: 27339069.

2016年

Tanaka K, Joyama S, Chuman H, Hiraga H, Morioka H, Yoshikawa H, Hosaka M, Takahashi M, Kubo T, Hatano H, Kaya M, Toguchida J, Nishida Y, Nagano A, Tsumura H, Iwamoto Y.

Feasibility and efficacy of gemcitabine and docetaxel combination chemotherapy for bone and soft tissue sarcomas: multi-institutional retrospective analysis of 134 patients.
World J Surg Oncol. 2016 Dec 8;14(1):306. PubMed PMID: 27931230; PubMed Central PMCID: PMC5146834.

Ishihara T, Miyazaki M, Yoshiiwa T, Notani N, Tsumura H.

Pyogenic vertebral osteomyelitis caused by Yersinia pseudotuberculosis. Joint Bone Spine. 2016 Dec;83(6):727-729. doi: 10.1016/j.jbspin.2016.01.009. Epub 2016 May 25. PubMed PMID: 27236259.

Miyazaki M, Yoshiiwa T, Ishihara T, Kawano M, Tsumura H.

Tuberculous Spondylitis following Intravesical Bacillus Calmette-Guerin for Bladder Cancer.
Case Rep Orthop. 2016;2016:6741284. doi: 10.1155/2016/6741284. Epub 2016 May 30. PubMed PMID: 27313927; PubMed Central PMCID: PMC4904083.

Yoshiiwa T, Miyazaki M, Kawano M, Ikeda S, Tsumura H.

Analysis of the Relationship between Hypertrophy of the Ligamentum Flavum and Lumbar SegmentalMotion with Aging Process.
Asian Spine J. 2016 Jun;10(3):528-35. doi:10.4184/asj.2016.10.3.528. Epub 2016 Jun 16. PubMed PMID: 27340534; PubMed Central PMCID: PMC4917773.

Kanezaki S, Miyazaki M, Notani N, Tsumura H.

Clinical presentation of geriatric polytrauma patients with severe pelvic fractures: comparison with younger adult patients.
Eur J Orthop Surg Traumatol. 2016 Dec;26(8):885-890. Epub 2016 Jul 22. PubMed PMID: 27448282.

Kaku N, Tabata T, Tsumura H.

Relationship between pull-out strength and oscillation angle in bipolar cups: an in vitro study. J Orthop Surg (Hong Kong). 2016 Aug;24(2):209-15. PubMed PMID: 27574265.

Yoshiiwa T, Miyazaki M, Notani N, Ishihara T, Kawano M, Tsumura H.

Analysis of the Relationship between Ligamentum Flavum Thickening and Lumbar SegmentalInstability, Disc Degeneration, and Facet Joint Osteoarthritis in Lumbar Spinal Stenosis.
Asian Spine J. 2016 Dec;10(6):1132-1140. Epub 2016 Dec 8. PubMed PMID:
27994791; PubMed Central PMCID: PMC5165005.

Kawano M, Tanaka K, Itonaga I, Iwasaki T, Tsumura H.

MicroRNA-301a promotes cell proliferation via PTEN targeting in Ewing's sarcoma cells. Int J Oncol. 2016 Feb 5.
PMID: 26846737

Tanaka K, Kawano M, Itonaga I, Iwasaki, Miyazaki M, Ikeda S, Tsumura H.

Tumor suppressive microRNA-138 inhibits metastatic potential via the targeting of focal adhesion kinase in Ewing's sarcoma cells. Int J Oncol. Jan 5.
PMID: 26782922

Kawano M, Tanaka K, Itonaga I, Iwasaki, Miyazaki M, Ikeda S, Tsumura H.

Dendritic cells combined with doxorubicin induces immunogenic cell death and exhibits antitumor effects for osteosarcoma. Oncology Letters 11: 2169-2175, 2016 Feb 2.

2015年

Kawano M, Tanaka K, Itonaga I, Iwasaki T, Tsumura H.

c-Myc Represses Tumor-Suppressive microRNAs, let-7a, miR-16 and miR-29b, and Induces Cyclin D2-Mediated Cell Proliferation in Ewing's Sarcoma Cell Line. PLOS One. Sep 22; 10 (9): e0138560.
PMID: 26393798

Kaku N, Tabata T, Tsumura H.

Influence of cup-center-edge angle on micro-motion at the interface between the cup and host bone in cementless total hip arthroplasty: three-dimensional finite element analysis. Eur J Orthop Surg Traumatol. Aug 29.
PMID: 26319002

Kawano M, Tanaka K, Itonaga I, Ikeda S, Iwasaki T, Tsumura H.

microRNA-93 promotes cell proliferation via targeting of PTEN in Osteosarcoma cells. Journal of Experimental & Clinical Cancer Research. Aug 5; 34 (1): 76
PMID; 26243299

Kawano M, Tanaka K, Itonaga I, Iwasaki, Miyazaki M, Ikeda S, Tsumura H.

Dendritic Cells Combined with Anti-GITR Antibody Produce Antitumor Effects in Osteosarcoma.
Oncology Reports. 2015, Jul 29.
PMID: 26239052

Hara K, Kaku N, Tabata T, Tsumura H.

Contact between the acetabulum and dome of a Kerboull-type plate influences the stress on the plate and screw.
Eur J Orthop Surg Traumatol. 2015 Jul; 25(5): 877-83.
PMID: 25749753

Miyazaki M, Kodera R, Yoshiiwa T, Kawano M, Kaku N, Tsumura H.

Prevalence and distribution of thoracic and lumbar compressive lesions in cervical spondylotic myelopathy.
Asian Spine J. 2015 Apr; 9 (2): 218-24.
PMID; 25901233

Tanaka K, Mizusawa J, Fukuda H, Araki N, Chuman H, Takahashi M, Ozaki T, Hiruma T, Tsuchiya H, Morioka H, Hatano H, Iwamoto Y.

Perioperative chemotherapy with ifosfamide and doxorubicin for high-grade soft tissue sarcomas in the extremities (JCOG0304).
Jpn J Clin Oncol. 2015 Jun; 45(6):555-61.
PMID:25838293

Iwasaki T, Tanaka K, Kawano M, Itonaga I, Tsumura H.

Tumor-suppressive microRNA-let-7a inhibits cell proliferation via targeting of E2F2 in osteosarcoma cells. Int J Oncol. 2015 Apr; 46(4):1543-50.
PMID: 25647078

Kawano M, Tanaka K, Itonaga I, Iwasaki, Miyazaki M, Ikeda S, Tsumura H.

Dendritic Cells Combined with Immunogenic Cell Death Induced by Doxorubicin Produces Antitumor Effects in Osteosarcoma.
Oncology Letters. 2015, in press.

2014年

Kaku N, Hara K, Tabata T, Tsumura H.

Fixation strength at the interface between
Kerboull-type plate and bone cement.
J Orthop Surg (Hong Kong). 2014 Dec;22(3):347-50.
PMID: 25550016

Tabata T, Kaku N, Hara K, Tsumura H.

Initial stability of cementless acetabular cups: press-fit and screw fixation interaction--an in vitro biomechanical study.
Eur J Orthop Surg Traumatol. 2015 Apr; 25(3):497-502.
PMID: 25421640

Kaku N, Tabata T, Tsumura H.

Mechanical evaluation of hip cement spacer reinforcement with stainless steel Kirschner wires, titanium and carbon rods, and stainless steel mesh.
Eur J Orthop Surg Traumatol. 2015 Apr; 25(3):489-96.
PMID: 25421639

Miyazaki M, Toyoda M, Yoshiiwa T, Kawano M, Kaku N, Tsumura H.

Enhancement of the effects of exfoliated carbon nanofibers by bone morphogenetic protein in a rat femoral fracture model.
J Orthop Res. 2015 Feb; 33(2):185-92.
PMID: 25346439

Kataoka K, Tanaka K, Mizusawa J, Kimura A, Hiraga H, Kawai A, Matsunobu T, Matsumine A, Araki N, Oda Y, Fukuda H, Iwamoto Y; Bone and Soft Tissue Tumor Study Group of the Japan Clinical Oncology Group.

A randomized phase II/III trial of perioperative chemotherapy with adriamycin plus ifosfamide versus gemcitabine plus docetaxel for high-grade soft tissue sarcoma: Japan Clinical Oncology Group Study JCOG1306.
Jpn J Clin Oncol. 2014 Aug; 44(8):765-9.
PMID: 24916336

Yoshiiwa T, Miyazaki M, Kodera R, Kawano M, Tsumura H.

Predictable imaging signs of cauda equina entrapment in thoracolumbar and lumbar burst fractures with greenstick lamina fractures.
Asian Spine J. 2014 Jun; 8(3):339-45.
PMID: 24967048

Kaku N, Hara K, Tabata T, Tsumura H.

Influence of the volume of bone defect, bone grafting methods, and hook fixation on stress on the Kerboull-type plate and screw in total hip arthroplasty: three-dimensional finite element analysis.
Eur J Orthop Surg Traumatol. 2015 Feb; 25(2):321-9.
PMID: 24964969

Miyazaki M, Yoshiiwa T, Ishihara T, Kaku N, Kawano M, Tsumura H.

Symptomatic spinal cord kinking due to focal adhesive arachnoiditis, with ossification of the ligamentum flavum: a case report.
Spine (Phila Pa 1976). 2014 Apr 15; 39(8):E538-41.
PMID: 24480938

Miyazaki M, Yoshiiwa T, Kodera R, Kawano M, Tsumura H.

Analysis of the prevalence and distribution of cervical and thoracic compressive lesions of the spinal cord in lumbar degenerative disease.
Asian Spine J. 2014 Feb; 8(1):19-26.
PMID: 24596601

2013年

Kodera R, Miyazaki M, Yoshiiwa T, Kawano M, Kaku N, Tsumura H.

Manipulation of anabolic and catabolic responses with bone morphogenetic protein and zoledronic acid in a rat spinal fusion model.
Bone.2014, Jan; 58: 26-32.
PMID: 24103577

Kawano M, Itonaga I, Iwasaki T, Tsumura H.

Enhancement of antitumor immunity by combining anti-cytotoxic T lymphocyte antigen-4 antibodies and cryotreated tumor lysate-pulsed dendritic cells in murine osteosarcoma.
Oncol Rep. 2013 Mar; 29 (3):1001-6. 2013 Jan 4.
PMID: 23291864

2012年

Kawano M, Itonaga I, Iwasaki T, Tsuchiya H, Tsumura H.

Anti-TGF-beta antibody combined with dendritic cells produce antitumor effects in osteosarcoma.
Clin Orthop Relat Res. 2012 Aug; 470(8): 2288-94.
PMID: 22415727

2011年

Miyazaki M, Yoshiiwa T, Kodera R, Tsumura H.

Clinical features of cervical pyogenic spondylitis and intraspinal abscess.
J Spinal Disord Tech. 2011 Oct;24(7):E57-61.
PMID: 21909038

Doi Y, Miyazaki M, Yoshiiwa T, Hara K, Kataoka M, Tsumura H.

Manipulation of the anabolic and catabolic responses with BMP-2 and zoledronic acid in a rat femoral fracture model.
Bone. 2011 Oct; 49(4):777-82.
PMID: 21777711

Yoshiiwa T, Miyazaki M, Takita C, Itonaga I, Tsumura H.

Analysis of measured D-dimer levels for detection of deep venous thrombosis and pulmonary embolism after spinal surgery.
J Spinal Disord Tech. 2011 Jun; 24(4):E35-9.
PMID: 20975598

2010年

Miyazaki M, Takita C, Yoshiiwa T, Itonaga I, Tsumura H.

Morphological analysis of the cervical pedicles, lateral masses, and laminae in developmental canal stenosis.
Spine (Phila Pa 1976). 2010 Nov 15; 35 (24):E1381-5.
PMID: 21030896

Miyazaki M, Morishita Y, Takita C, Yoshiiwa T, Wang JC, Tsumura H.

Analysis of the relationship between facet joint angle orientation and lumbar spine canal diameter with respect to the kinematics of the lumbar spinal unit.
J Spinal Disord Tech. 2010 Jun; 23 (4):242-8. 
PMID: 20068469

Kawano M, Nishida H, Nakamoto Y, Tsumura H, Tsuchiya H.

Cryoimmunologic antitumor effects enhanced by dendritic cells in osteosarcoma.
Clin Orthop Relat Res. 2010 May; 468(5):1373-83.
PMID: 20232181

2005年

Miyazaki M, Takasita M, Matsumoto H, Sonoda H, Tsumura H, Torisu T.

Spinal epidural hematoma after removal of an epidural catheter: case report and review of the literature.
J Spinal Disord Tech. 2005 Dec;18(6):547-51.
PMID: 16306849 [PubMed - in process]

Tsumura H, Torisu T, Kaku N, Higashi T.

Five- to fifteen-year clinical results and the radiographic evaluation of acetabular changes after bipolar hip arthroplasty for femoral head osteonecrosis.
J Arthroplasty. 2005 Oct;20(7):892-7.
PMID: 16230241 [PubMed - in process]

Sawatari T, Tsumura H, Iesaka K, Furushiro Y, Torisu T.

Three-dimensional finite element analysis of unicompartmental knee arthroplasty--the influence of tibial component inclination.
J Orthop Res. 2005 May;23(3):549-54. Epub 2005 Mar 23.
PMID: 15885474 [PubMed - indexed for MEDLINE]

Tsumura H, Ikeda S, Torisu T.

Debridement and continuous irrigation for the treatment of pyogenic arthritis caused by the use of intra-articular injection in the osteoarthritic knee: indications and outcomes.
J Orthop Surg (Hong Kong). 2005 Apr;13(1):52-7.
PMID: 15872401 [PubMed - indexed for MEDLINE]

Tsumura H, Kaku N, Torisu T.

Does the self-centering mechanism of bipolar hip endoprosthesis really work in vivo?
J Orthop Surg (Hong Kong). 2005 Apr;13(1):46-51.
PMID: 15872400 [PubMed - indexed for MEDLINE]

Tsumura H, Kaku N, Ikeda S, Torisu T.

A computer simulation of rotational acetabular osteotomy for dysplastic hip joint: does the optimal transposition of the acetabular fragment exist?
J Orthop Sci. 2005;10(2):145-51.
PMID: 15815861 [PubMed - in process]

Ikeda S, Tsumura H, Torisu T.

Age-related quadriceps-dominant muscle atrophy and incident radiographic knee osteoarthritis.
J Orthop Sci. 2005;10(2):121-6.
PMID: 15815857 [PubMed - in process]

Tsumura H, Ikeda S, Ono T, Itonaga I, Taira H, Torisu T.

Synovectomy, debridement, and continuous irrigation for infected total knee arthroplasty.
Int Orthop. 2005 Apr;29(2):113-6. Epub 2005 Feb 1.
PMID: 15685455 [PubMed - indexed for MEDLINE]

2004年

Kataoka M, Tsumura H, Itonaga I, Kaku N, Torisu T.

Subchondral cyst of the tibia secondary to Wilson disease.
Clin Rheumatol. 2004 Oct;23(5):460-3. Epub 2004 May 15.
PMID: 15459818 [PubMed - indexed for MEDLINE]

宮崎正志,高木一広

外傷性股関節脱臼骨折の検討,整形外科と災害外科,53(2),259-264,2004

宮崎正志,高下光弘,松本博文,立山正道,河野正典,津村 弘

脊髄硬膜下血腫の1症例,整形外科と災害外科,53(2),389-393,2004

吉岩豊三,加来信広,平 博文,津村 弘

EOG滅菌された凍結乾燥骨の臨床使用上の問題点,整形外科と災害外科,53(2),436-440,2004

津村 弘

人工膝関節置換術における可動域の改善,大分県整形外科医会誌,vol23,2004

加来信広,津村 弘,高下光弘,片岡晶志,鳥巣岳彦

RAの下肢多関節手術症例の検討, 臨床リウマチ16:134-140,2004

加来信広,津村 弘

感染人工股関節に対するバイポーラ型人工骨頭を用いた再建術,整形外科 55(8),1004-1014,2004

加来信広,津村 弘,日隈康雄,土肥有二,鳥巣岳彦

急速破壊型股関節症に対するbipolar型人工骨頭置換術の臨床成績日本リウマチ・関節外科学会,23(1),37-44,2004

川嶌眞之, 高下光弘, 藤川陽祐, 東  努, 津村 弘, 鳥巣岳彦

高度に破壊された足関節に対してフィン付き髄内釘による関節固定術を行ったが骨癒合の得られなかったムチランス型関節リウマチの1症例,臨床リウマチ,16(3),230-234,2004

小埜 崇,津村 弘,熊木光包,糸永一朗

LPS-Flex型人工膝関節の短期成績 mobile型とfixed型の選択について,九州リウマチ, 24(1),49-53,2004

Kaku N, Tsumura H, Taira H, Sawatari T, Torisu T

Biomechanical study of load transfer of the public ramus due to oelvic inclination after hip joint surgery using a three-dimensional finite element model,Journal of Orthopaedic Science9(3),264-269,2004

Kataoka M, Tsumura H, Itonaga I, Kaku N, Torisu T

Subchondralcyst of the tibia secondary to Wilson disease Clin Rheumatol,(23),460-463,2004

Itonaga I, A.Sabokbar, S.G.Sun, O.Kudo, L.Danks, D.Ferguson, Y.Fujikawa, N.A.Athanasou

Transforming growth factor-βinduces osteoclast formation in the absence of RANKL Bone34(2004) 57-64

Iesaka K

Thermal factors affecting stability and durability of cemented metal prostheses J Biomech 37(3),422,2004

Iesaka K, Jaffe WL, Kummer FJ

Effects of the inital temperature of acrylic bone cement Liquid monomer on the properties of the stem-cement J Biomed Mater Res 15;68B(2),186-90,2004

D.J.P.Ferguson, Itonaga I, Maki M, McNally E, Gundle R, N.A.Athanasou

Heterotopic bone formation following hip arthroplasty in Paget’s disease,Bone34,1078-1083,2004

著書Book

津村 弘

特集 膝の深屈曲人工関節(企画),整形・災害外科vol.47:128,2004

鳥巣岳彦

関節リウマチ,関節液混濁と人工関節手術 関節の外科 (日本リウマチ研究会誌)31(1):1-4,2004

鳥巣岳彦

関節の診察法,関節リウマチの診療マニュアル(改訂版)診断のマニュアルとEBMに基づく治療ガイドライン,財団法人日本リウマチ財団,54-62,2004

鳥巣岳彦

<日本骨・感染症研究会>軟部組織・骨・関節の感染症をICDの関わり方,感染制御 1(1):11-16,2004

鳥巣岳彦

関節リウマチの診断 関節の診察法 CLINICIAN:No530(51)21-24,2004

総説Review

鳥巣岳彦

AAOS Annual Selection Q&A30,7-10,2004

鳥巣岳彦

今日の整形外科治療指針 第5版,149-151,医学書院,2004

鳥巣岳彦

今日の整形外科治療指針 第5版,166-169,医学書院,2004

鳥巣岳彦

標準感染症学 第2版343-353,医学書院,2004

鳥巣岳彦

内科・整形外科のための関節リウマチの機能再建手技の実際,81-96,メディカルレビュー社,2004

鳥巣岳彦

内科・整形外科のための関節リウマチ機能再建手技の実際,97-110,メディカルレビュー社,2004

高下光弘,鳥巣岳彦

NEW MOOK整形外科14 リウマチ類縁疾患,17-32,金原出版,2004

田仲和宏

がん治療認定医教育セミナーテキスト第10版  2016 骨・軟部腫瘍 

田仲和宏

今日の整形外科治療指針第7版,土屋弘行,紺野慎一,田中康仁,田中栄,松田秀一編,医学書院,p179-182、2016 悪性骨軟部腫瘍の化学療法